Abstract #1101

Two compartment quantitative transport mapping: evaluating tracer exchange rate between vascular and extravascular space

Qihao Zhang¹, Jin Zhang², Gene Kim², John Morgan², Thanh Nguyen², Pascal Spincemaille², and Yi Wang¹

¹Cornell University, New York, NY, United States, ²Weill Cornell Medical College, New York, NY, United States

In this study, we introduce compartment modeling into quantitative transport mapping (QTM), with the goal of mapping both the blood flow and the tracer exchange between vascular space and extravascular space. The nonlinear optimization problem is solved using the Levenberg–Marquardt method. We validate two compartment QTM (2c-QTM) in a porous media simulation and apply this method to dynamic PET data.

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