We propose to assess the severity of Nonalcoholic fatty liver disease (NAFLD) using quantitative transport mapping (QTM), a recently introduced flow quantification method. A numerical simulation was performed to compare QTM with traditional kinetic modeling. QTM successfully reconstructed blood flow with high accuracy (relative root mean square error = 0.27). Using DCE MRI in 5 adult rats with methionine choline-deficient diet-induced NAFLD (grade F3) and in 13 untreated control rats, only the QTM derived velocity |u| showed a significant difference between NAFLD and healthy controls.
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