Meeting Banner
Abstract #1106

Assessment of Fatty liver disease in rats using quantitative transport mapping (QTM) method against pathology validation

Qihao Zhang1, Xianfu Luo2, Thanh Nguyen2, Pascal Spincemaille2, and Yi Wang1
1Cornell University, New York, NY, United States, 2Weill Cornell Medical College, New York, NY, United States

We propose to assess the severity of Nonalcoholic fatty liver disease (NAFLD) using quantitative transport mapping (QTM), a recently introduced flow quantification method. A numerical simulation was performed to compare QTM with traditional kinetic modeling. QTM successfully reconstructed blood flow with high accuracy (relative root mean square error = 0.27). Using DCE MRI in 5 adult rats with methionine choline-deficient diet-induced NAFLD (grade F3) and in 13 untreated control rats, only the QTM derived velocity |u| showed a significant difference between NAFLD and healthy controls.

This abstract and the presentation materials are available to members only; a login is required.

Join Here