High spatial-temporal resolved perfusion imaging: simultaneously DCE- and DSC-MRI acquisition using improved Spiral-Out-In (iSOI) sequence

The combination of DCE and DSC MRI contribute to the higher accuracy of diagnosis than either alone. However, high spatial-temporal resolution sequences for DCE and DSC are absent in the clinical use. Herein, we propose an improved Spiral-Out-In (iSOI) sequence to simultaneously sample DCE and DSC signal with high spatial resolution. A model-based strategy for reconstruction of 8-fold accelerated MRI were employed to realize high temporal resolution imaging. The in-plane spatial resolution is 0.78 mm and the temporal resolution is 0.52 s. The perfusion parameters were calculated to verify the proposed method which has potential to benefit the accurate diagnosis.