Abstract #1130

Quantitative evaluation of different models of diffusion-weighted MRI for the correlation with molecular subtype of breast cancer

Muzhen He¹, Huiping Ruan¹, Mingping Ma², Zhongshuai Zhang³, and Robert Grimm³

¹Radiology, Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China, ²Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China, ³Siemens Healthcare Ltd, Shanghai, China

This study aimed to compare the performance of different diffusion models of，including the mono-exponential, intravoxel incoherent motion (IVIM) model and the diffusion kurtosis imaging (DKI) model，for the correlation with molecular subtype and molecular prognostic factors. The results indicate that ADC, IVIM-D, DKI-D can be used to differentiate luninal B group from others molecular subtype. Quantitative MR diffusion parameters, such as ADC ,DKI-K, DKI-D , IVIM-FP and IVIM-D were significantly associated with HER2 overexpression, Ki-67 proliferation status and histological grade in patients with breast cancer.

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