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Abstract #1150

Time-dependent IVIM/Non-Gaussian parameters between in vivo and post-mortem breast cancer xenograft models

Yuko Someya1, Mami Iima1,2, Hirohiko Imai3, Hiroyoshi Isoda1, Masako Kataoka1, Denis Le Bihan4,5,6, and Yuji Nakamoto1
1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, Japan, 2Department of Clinical Innovative medicine, Institute for advancement of clinical and translational science, Kyoto University Hospital, Kyoto, Japan, 3Department of Systems science, Graduate School of Informatics, Kyoto University, Kyoto, Japan, 4NeuroSpin/Joliot, CEA-Saclay Center, Paris-Saclay University, Gif-sur-Yvette, France, 5Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 6National Institute for Physiological Sciences, Okazaki, Japan

We investigated the time-dependency of IVIM /non-Gaussian diffusion parameters in vivo and post-mortem using breast xenograft models (MDA-MB-231). fIVIM, perfusion-related fraction, dropped abruptly post-mortem, though not reaching 0 completely, suggesting imperfect modeling. fIVIM, estimated from the pseudo-diffusion model, was independent of the diffusion time. The significant decrease of sADC and ADC0 values and the increase in K values observed between short and long diffusion times, as well as after sacrification are in accordance with an increase in diffusion hindrance, as more water molecules hit many boundaries, such as cell membranes. However, different mechanisms may be at stake.

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