Abstract #1150

Time-dependent IVIM/Non-Gaussian parameters between in vivo and post-mortem breast cancer xenograft models

Yuko Someya¹, Mami Iima^1,2, Hirohiko Imai³, Hiroyoshi Isoda¹, Masako Kataoka¹, Denis Le Bihan^4,5,6, and Yuji Nakamoto¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, Japan, ²Department of Clinical Innovative medicine, Institute for advancement of clinical and translational science, Kyoto University Hospital, Kyoto, Japan, ³Department of Systems science, Graduate School of Informatics, Kyoto University, Kyoto, Japan, ⁴NeuroSpin/Joliot, CEA-Saclay Center, Paris-Saclay University, Gif-sur-Yvette, France, ⁵Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁶National Institute for Physiological Sciences, Okazaki, Japan

We investigated the time-dependency of IVIM /non-Gaussian diffusion parameters in vivo and post-mortem using breast xenograft models (MDA-MB-231). f_IVIM, perfusion-related fraction, dropped abruptly post-mortem, though not reaching 0 completely, suggesting imperfect modeling. f_IVIM, estimated from the pseudo-diffusion model, was independent of the diffusion time. The significant decrease of sADC and ADC₀ values and the increase in K values observed between short and long diffusion times, as well as after sacrification are in accordance with an increase in diffusion hindrance, as more water molecules hit many boundaries, such as cell membranes. However, different mechanisms may be at stake.

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