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Abstract #1180

Improved Sampling for Distortionless Diffusion Weighted 2D Cartesian Multi-Shot Fast Spin Echo

Philip Kenneth Lee1,2, Yuxin Hu1,2, Catherine Judith Moran2, Bruce Lewis Daniel2, and Brian Andrew Hargreaves1,2,3
1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Biomedical Engineering, Stanford University, Stanford, CA, United States

In diffusion weighted imaging, multi-shot Echo Planar Imaging (EPI) is preferred over single-shot EPI due to reduced geometric distortion. Recent work has shown that low-rank reconstructions can correct ghosts from shot-to-shot phase without explicitly acquiring a phase navigator. These works have been limited to EPI sampling trajectories with uniform ky sampling. 2D Cartesian Fast Spin Echo (FSE) is a distortionless alternative to multi-shot EPI that has greater freedom in k-space traversal and reduced chemical shift artifacts. Using FSE, we demonstrate in simulation and in vivo that an intelligent choice of sampling pattern greatly enhances image quality in multi-shot diffusion imaging.

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