Abstract #1209

Changes in Correlation Between Brain Metabolites Due to Acute Stress in Mouse Hippocampus using Proton Magnetic Resonance Spectroscopy

Chang-Soo Yun¹, Yoon Ho Hwang², Min-Hee Lee³, Wooseung Kim², Jehyeong Yeon¹, Hyeon-Man Baek⁴, Dong Youn Kim², and Bong Soo Han¹

¹Radiation Convergence Engineering, Yonsei University, Wonju-si, Gangwon-do, Korea, Republic of, ²Biomedical Engineering, Yonsei University, Wonju-si, Gangwon-do, Korea, Republic of, ³Institute of Human Genomic Study, Korea University, Ansan-si, Gyeonggi-do, Korea, Republic of, ⁴Gachon Advanced Institute for Health Sciences and Technology, Gachon University, Incheon-si, Korea, Republic of

We investigated the changes in correlation between mouse brain metabolites due to acute restraint stress using magnetic resonance spectroscopy (MRS). Acquired time series MRS data of the control and acute stress groups were quantified using LCModel. Correlation coefficients between metabolites were calculated from time series metabolite concentration and metabolite pairs with statistically significant correlations were selected using one-sample Sign Test ( p < 0.05 ). We found that Gln-GSH, NAA-Glu and NAA-GSH showed new significant correlations in the acute stress group. Our findings suggest that correlation can be a useful measurement in assessing the effects of stress.

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