Magnetic particle imaging (MPI) is an emerging modality that may overcome challenges associated with quantification of iron-based MRI cell tracking. The magnetic properties of an SPION tracer heavily influences the sensitivity and resolution in MPI. Synomag-D™ has been explored as a sensitive tracer for MPI. Currently, no studies exist using this tracer to track cancer cells. Here, we utilize Synomag-D with MPI to detect and quantify iron-labeled breast cancer cells in the mouse brain and compare to MRI. Employing MPI for experimental cancer cell tracking will allow for quantification of the arrest, clearance, and retention of cancer cells in vivo.
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