Abstract #1249

Comprehensive multiparametric cardiac MRI tissue phenotyping (LGE, T1, T2, DWI, BOLD & VAI) of acute myocardial infarction in swine

Holly Doig¹, Maaike van den Boomen^1,2,3, Erin Connors¹, Joan Kim¹, Jaume Coll-Font^1,3, Robert A. Eder¹, Shi Chen¹, Yoshiko Iwamoto¹, Kyrre E. Emblem⁴, Kawin Setsompop³, Niek H.J. Prakken², Ronald J.H. Borra^2,5, and Christopher T. Nguyen^1,3

¹Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, University Medical Center Groningen, Groningen, Netherlands, ³A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ⁴Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway, ⁵Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, Netherlands

Myocardial infarction (MI) and ischemic reperfusion (IR) injury are a common western world problem and are aimed to be better understood by imaging techniques to enable non-invasive longitudinal follow up. Novel MRI based techniques, such as cardiac DWI, BOLD and VAI, are emerging and detailed assessment and comparison with current golden standard and histology is needed to determine their role in treatment planning and revalidation of MI patients. Here we show that specifically BOLD can be used as an early marker in the acute MI phase.

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