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Abstract #1251

In-vivo ferumoxytol imaging and T1/T2 characterization at 64mT

Thomas Campbell Arnold1, Samantha By2, Hadrien Dyvorne2, Rafael O'Halloran2, Farzana Sayani3, Lisa M. Desiderio4, Brian Litt1,5, and Joel M. Stein4
1Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Hyperfine Research, Guilford, CT, United States, 3Medicine, Perelman School of Medicine, Philadelphia, PA, United States, 4Radiology, Perelman School of Medicine, Philadelphia, PA, United States, 5Neurology, Perelman School of Medicine, Philadelphia, PA, United States

MRI provides superior imaging for diverse clinical applications, but cost and other factors limit availability in various healthcare and lower resource settings. Low-field strength units promise to expand access but involve trade-offs including reduced signal, longer acquisitions, and uncertain benefit of contrast agents. Here we characterize T1 and T2 properties of ferumoxytol, an iron oxide agent with prolonged blood pool phase and higher R1 and R2 values than gadolinium, on a 64mT portable system. We demonstrate enhancement across a range of concentrations in phantoms and visualization of cerebral vasculature in patients receiving the agent for iron-deficiency anemia.

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