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Abstract #1253

High neuromelanin contrast achieved using sandwiched flow saturation RF pulses: sandwich-fsNM imaging

Sooyeon Ji1, Eun-Jung Choi1, Eung Yeop Kim2, Dong Hoon Shin3, Hyeong-Geol Shin1, and Jongho Lee1
1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 2Department of Radiology, Gachon University Gil Medical Center, Incheon, Korea, Republic of, 3Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea, Republic of

A neuromelanin-sensitive imaging protocol based on a GRE sequence, sandwich-fsNM, is developed using multiple flow saturation pulses instead of MT pulses. The flow saturation pulses are located both superior and inferior to the imaging volume, like a sandwich, to avoid asymmetric MT across slices. The proposed protocol yields higher contrast between crus cerebri and substantia nigra and better visualizes locus coeruleus, compared to MT prepared GRE or TSE sequences.

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