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Abstract #1280

Concordance of Regional Hypoperfusion by ASL MRI and 15O-water PET in Frontotemporal Dementia: Is ASL an Efficacious Alternative?

Tracy Ssali1, Lucas Narciso1,2, Justin Hicks1,2, Matthais G√ľnther3, Frank Prato1,2, Udunna Anazodo1,2, Elizabeth Finger4, and Keith St Lawrence1,2
1Lawson Health Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany, 4Department of Clinical Neurological Sciences, Western University, London, ON, Canada

The ability of arterial spin labeling (ASL) to detect perfusion abnormalities in clinical populations can be limited by poor signal to noise and transit-time artefacts. This is evident in studies involving frontotemporal dementia patients, where reports on the diagnostic value of ASL have been inconsistent. This study presents a head-to-head comparison of regional hypoperfusion detected by ASL and PET with radiolabeled water (15O-water), the gold standard for measuring CBF. T-maps depicting hypoperfusion were generated using absolute and relative CBF. There was good agreement between regional hypoperfusion identified by ASL and 15O-water, particularly for relative CBF maps which reduced inter-subject variability.

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