Abstract #1280

Concordance of Regional Hypoperfusion by ASL MRI and 15O-water PET in Frontotemporal Dementia: Is ASL an Efficacious Alternative?

Tracy Ssali¹, Lucas Narciso^1,2, Justin Hicks^1,2, Matthais Günther³, Frank Prato^1,2, Udunna Anazodo^1,2, Elizabeth Finger⁴, and Keith St Lawrence^1,2

¹Lawson Health Research Institute, London, ON, Canada, ²Department of Medical Biophysics, Western University, London, ON, Canada, ³Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany, ⁴Department of Clinical Neurological Sciences, Western University, London, ON, Canada

The ability of arterial spin labeling (ASL) to detect perfusion abnormalities in clinical populations can be limited by poor signal to noise and transit-time artefacts. This is evident in studies involving frontotemporal dementia patients, where reports on the diagnostic value of ASL have been inconsistent. This study presents a head-to-head comparison of regional hypoperfusion detected by ASL and PET with radiolabeled water (¹⁵O-water), the gold standard for measuring CBF. T-maps depicting hypoperfusion were generated using absolute and relative CBF. There was good agreement between regional hypoperfusion identified by ASL and ¹⁵O-water, particularly for relative CBF maps which reduced inter-subject variability.

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