A Combined Cluster analysis of time evolution and tissue type with Total Variation denoising (CCTV) was developed to suppress noise propagation in oxygen extraction fraction (OEF) maps based on the QSM+qBOLD (QQ) model of multi-echo gradient echo data without vascular challenge. Compared to cluster analysis of time evolution (CAT), the developed CCTV provided more accurate OEF in simulation and greater contrast to noise ratio between lesion and its healthy contralateral side in ischemic stroke patients.
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