Abstract #1295

Regional Brain Perfusion Changes in Cognition and Mood Regulatory Sites in Patients with Type 2 Diabetes Mellitus

Bhaswati Roy¹, Sarah Choi², Matthew J. Freeby ³, and Rajesh Kumar^1,4,5,6

¹Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, ²School of Nursing, University of California Los Angeles, Los Angeles, CA, United States, ³Medicine, Endocrinology - Diabetes and Metabolism, University of California Los Angeles, Los Angeles, CA, United States, ⁴Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ⁵Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁶Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States

Patients with Type 2 diabetes mellitus (T2DM) show cognitive and mood changes, and brain tissue injury in those regulatory regions. However, underlying cause of tissue damage in cognition and mood regulatory sites, and their associations with these functional deficits in T2DM remain unclear. We evaluated cerebral blood flow (CBF) in T2DM patients over controls, and found changes in the frontal and prefrontal cortices, cerebellum, hippocampus, cingulate, insula, thalamus, and basal-forebrain, sites involved regulating mood and cognition. Significant correlations emerged between CBF and functional deficits in T2DM, including mood and cognition symptoms, implying the altered hemodynamic contributing to the functional deficits.

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