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Abstract #1297

Regional Brain Growth in Fetuses with Congenital Diaphragmatic Hernia

Fedel Machado-Rivas1,2, Lina Acosta Buitrago3, Jungwhan J Choi1,2, Onur Afacan1,2, Clemente Velasco-Annis1, Simon K Warfield1,2, Ali Gholipour1,2, and Camilo Jaimes1,2
1Radiology, Boston Children's Hospital, Boston, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Universidad del Rosario, Bogota, Colombia

Brain growth trajectories of fetal subjects with congenital diaphragmatic hernia (CDH) were compared to typically developing fetuses. T2-weighted SSFSE acquisitions were reconstructed to a super-resolution volume and atlas-based segmentations of brain structures were propagated. Gestational age, sex, segment volumes, and morphological hernia metrics (for CDH subjects) were analyzed in 71 fetuses with CDH and in 50 controls. We found lower brain volumes relative to normal fetuses in the developing white matter, hippocampus, diencephalon, and deep gray structures. Metrics associated with greater hernia severity were associated with lower volumes. Furhermore, our analysis shows that right-sided hernias were associated with lower volumes.

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