Brain growth trajectories of fetal subjects with congenital diaphragmatic hernia (CDH) were compared to typically developing fetuses. T2-weighted SSFSE acquisitions were reconstructed to a super-resolution volume and atlas-based segmentations of brain structures were propagated. Gestational age, sex, segment volumes, and morphological hernia metrics (for CDH subjects) were analyzed in 71 fetuses with CDH and in 50 controls. We found lower brain volumes relative to normal fetuses in the developing white matter, hippocampus, diencephalon, and deep gray structures. Metrics associated with greater hernia severity were associated with lower volumes. Furhermore, our analysis shows that right-sided hernias were associated with lower volumes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords