Abstract #1299

White Matter fiber orientation dependent R2*: comparison between post mortem in situ and in vivo

Celine Berger^1,2, Claudia Lenz^1,2, Melanie Bauer^1,2, Eva Scheurer^1,2, and Christoph Birkl³

¹Institute of Forensic Medicine, Department of Biomedical Engineering, Basel, Switzerland, ²Institute of Forensic Medicine, Health Department Basel-Stadt, Basel, Switzerland, ³Department of Neuroradiology, Medical University of Innsbruck, Austria

White matter R₂^* imaging is sensitive to the fiber orientation with respect to the main magnetic field. This study compared fiber orientation dependent R₂^* of white matter in post mortem (pm) in situ and in vivo based on an identical technical approach using diffusion tensor imaging to estimate the fiber angle. R₂^* increased with increasing fiber angle in both groups, whereby a decreased R₂^* orientation sensitivity was observed post mortem compared to in vivo. This may be mainly caused by the decreased pm brain temperature compared to in vivo conditions leading to reduced diffusion and by tissue decomposition after death.

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