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Abstract #1324

Multi-shot diffusion MRI of the human brain with motion-compensated oscillating gradients

Eric Seth Michael1, Franciszek Hennel1, and Klaas Paul Pruessmann1
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland

High-resolution multi-shot acquisitions are commonly avoided in diffusion MRI because motion-related phase instability, which can result from diffusion encoding schemes with a nonzero first moment, often hampers image reconstruction. This issue can be circumvented through the use of motion-compensated diffusion gradient shapes derived from oscillating gradient spin-echo (OGSE) methodologies. The utility of this solution is demonstrated here for interleaved spiral scans performed using a high-performance gradient system. The robustness against motion of OGSE sequences provided a notable advantage compared to a standard diffusion sensitization sequence for the phase stability and subsequent quality of multi-shot acquisitions.

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