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Abstract #1420

Brain perfusion imaging using pseudo-continuous arterial spin labelling MRI: impact of RF coil shimming of the labelling region

Sofia Guterres1, Ana Rodrigues Fouto1, Nuno André Silva2, Pedro Vilela3, and Patrícia Figueiredo1
1Institute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal, 2Hospital da Luz Learning Health, Lisboa, Portugal, 3Hospital da Luz, Lisboa, Portugal

The labelling efficiency of pCASL perfusion imaging sequences can be hampered by B0 field inhomogeneities. We assessed the impact of shimming the labelling region using a commercial RF coil with dedicated shiming channels in the neck, on data acquired from healthy volunteers. Brain perfusion was quantified, as well as the labelling efficiency (based on B0 fieldmaps and numerical simulations). Simulation experiments show that labelling efficiency significantly depends on B0 field inhomogeneity. In vivo experiments, however, showed subtle inhomogeneity reduction within the arteries in the labelling region, yielding no significant improvements in pCASL labelling efficiency or the respective perfusion signal.

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