Abstract #1431

Kinetic parameters derived from ultrafast DCE-MRI to predict breast cancer response to neoadjuvant chemotherapy

Zhen Ren¹, Federico D Pineda¹, Elle Hill¹, Teodora Szasz¹, Rabia Safi¹, Chengyue Wu², Thomas E Yankeelov², Kirti Kulkarni¹, Hiroyuki Abe¹, Rita Nanda¹, and Gregory S Karczmar¹

¹University of Chicago, Chicago, IL, United States, ²The University of Texas at Austin, Austin, TX, United States

We retrospectively reviewed data from 11 patients who received NAC and were scanned with a protocol that included ultrafast DCE-MRI for the first minute after contrast injection, followed by high spatial-resolution post-contrast imaging prior to therapy and post-treatment. The results showed a significant correlation between response to therapy and the contrast media bolus arrival time (BAT) in tumor, and normal parenchyma in each breast separately. In addition, BAT is significantly associated with background parenchymal enhancement (BPE) while BPE rate is independent of BPE. BPE rate and tumor enhancement rate may be independent predictors for malignancy.

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