Abstract #1433

Predictive value of APTw for early evaluation of pathological complete response to NAC in molecular subtyping of breast cancer

Nan Zhang¹, Lina Zhang¹, Qingwei Song¹, Ailian Liu¹, Keshuo Tang², Lei Dong², Jiazheng Wang³, and Zhiwei Shen³

¹The First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Dalian Medical University, Dalian, China, ³Philips Healthcare, Beijing, China, Beijing, China

Amide proton transfer (APT) imaging is based on the chemical exchange between free bulk water protons and the amide protons (-NH) of endogenous mobile proteins and peptides in tissue[1]. Nan Meng et al suggested that APTw imaging can be used for the differential diagnosis of benign and malignant breast lesions[2]. A simple sample study has shown that APTw MRI provides a possible biomarker for assessing chemotherapy response in human breast cancer patients on 3T MRI[3]. This study aims to explore the feasibility of APTw-MRI in early evaluation of pathological complete response to NAC in molecular subtyping of breast cancer

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