Tentative assignment of methylmalonic acid in the breast tissue using in vivo 2D COSY and relationships with risk factors of breast cancer

Methylmalonic acid (MMA) has been linked to ageing and a systemic environment that favours the progression and tumours aggressiveness. We aim to assign MMA in breast tissue using in vivo 2D COSY in a series of 172 participants including women at average and elevated risk. A second purpose is to explore if MMA is associated with breast cancer risk factors. Two resonances were recorded at 3.15 and 3.19ppm in breast tissue, consistent with the presence of MMA1 and MMA2 molecules. The level of MMA correlates positively with breast density/menopausal status and IBIS risk score and, negatively with age and BMI.