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Abstract #1459

­­Simultaneous mapping of B0, B1 and T1 for the correction of CEST-MRI

Kerstin Heinecke1, Henrik Narvaez1, Christoph Kolbitsch1, and Patrick Schuenke1
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany

One of the bottlenecks in Chemical Exchange Saturation Transfer (CEST) MRI is its susceptibility to magnetic field inhomogeneities and dependency on T1 relaxation times. To enable efficient correction for these parameters, we propose a new method for simultaneous quantitative mapping of B0, B1 and T1 using a simple CEST sequence with a modified preparation block. For the analysis, we developed a neural network that provides an additional uncertainty estimation for each parameter. First results on phantom simulations demonstrate the feasibility of this approach as well as its applicability for the correction of CEST-MRI data.

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