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Abstract #1461

MTC removed and exchange rate differentiated CEST using Variable Delay Multi Pulse (VDMP) in the human brain at 7T 

Bárbara Schmitz Abecassis1, Elena Vinogradov Vinogradov2,3, Jannie P. Wijnen4, Thijs van Harten1, Evita C. Wiegers4, Hans J.M. Hoogduin4, Matthias J.P. van Osch 1, and Ece Ercan1
1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 4Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Variable-delay multi-pulse (VDMP) is a chemical exchange saturation transfer (CEST) editing technique relying on the exchange rate as a filter to separate the CEST- effect from different solute pools. We investigated this method to evaluate CEST-effects from metabolites and proteins in in vivo human brain at 7T. We removed the pronounced magnetization transfer contrast present in vivo via Lorentzian-fittings, and evaluated the effect of B1 on saturation build-up curves of the different CEST-pools. MTC-removed VDMP-curves from the human brain are reported for the first time, where the effect of slow and fast exchanging protons allows distinguishing different CEST-pools.

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