Abstract #1461

MTC removed and exchange rate differentiated CEST using Variable Delay Multi Pulse (VDMP) in the human brain at 7T

Bárbara Schmitz Abecassis¹, Elena Vinogradov Vinogradov^2,3, Jannie P. Wijnen⁴, Thijs van Harten¹, Evita C. Wiegers⁴, Hans J.M. Hoogduin⁴, Matthias J.P. van Osch ¹, and Ece Ercan¹

¹Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ³Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Variable-delay multi-pulse (VDMP) is a chemical exchange saturation transfer (CEST) editing technique relying on the exchange rate as a filter to separate the CEST- effect from different solute pools. We investigated this method to evaluate CEST-effects from metabolites and proteins in in vivo human brain at 7T. We removed the pronounced magnetization transfer contrast present in vivo via Lorentzian-fittings, and evaluated the effect of B₁ on saturation build-up curves of the different CEST-pools. MTC-removed VDMP-curves from the human brain are reported for the first time, where the effect of slow and fast exchanging protons allows distinguishing different CEST-pools.

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