Abstract #1465

Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open source sequence standard

Kai Herz^1,2, Sebastian Mueller¹, Maxim Zaitsev³, Linda Knutsson^4,5, Jinyuan Zhou⁵, Phillip Zhe Sun⁶, Peter van Zijl^5,7, Klaus Scheffler^1,2, and Moritz Zaiss^1,8

¹Magnetic Resonance Center, MPI for Biological Cybernetics, Tuebingen, Germany, ²Biomedical Magnetic Resonance, University of Tuebingen, Tuebingen, Germany, ³Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ⁴Medical Radiation Physics, Lund University, Lund, Sweden, ⁵Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Yerkes Imaging Center, Emory University, Atlanta, GA, United States, ⁷F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁸Neuroradiology, Friedrich‐Alexander Universität Erlangen‐Nuernberg, Erlangen, Germany

The design of the preparation period is crucial for a CEST experiment, thus, a common, easy-to-use and vendor-independent file format to share exact preparation parameters is desirable. Here, we propose the use of Pulseq to define CEST parameters in an open source and human-readable file format. By providing a protocol database, a pulseq-compatible Bloch-McConnell simulation and a hybrid sequence using Pulseq for CEST preparation, we present a straightforward approach to standardize, share, simulate and measure different CEST preparation schemes, which are inherently completely defined.

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