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Abstract #1467

A comparison of several tumor endogenous pH mapping methods using CEST at 11.7T

Ying Liu1,2, Botao Zhao1,2, and Xiao-Yong Zhang1,2
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

CEST-MRI has emerged as a noninvasive pH imaging technique based on the pH-dependence of the prototropic exchange rates. In this work, we compared several recently published CEST pH imaging methods and proton exchange rate value in rat glioma models at 11.7T. All of these pH-weighted contrasts show a pH correlation and have significantly different signal intensities between the tumor region and the surrounding normal tissue. Our results demonstrated that pH enhanced method and APT imaging are not concentration-independent while the sensitivity of AACID is affected by the weak amine signals at 2.7ppm.

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