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Abstract #1469

Investigating MT and CEST Characteristics of DU145 Prostate Tumour Xenografts in Relation to Radiation Treatment Response

Leedan Murray1, Wilfred W. Lam1, and Greg J. Stanisz1,2
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada

MT and CEST characteristics of DU145 prostate tumour xenografts with known responses to radiation treatment were investigated to determine characteristics that may predict treatment response. After excision for histology, tumours were categorized according to their response to treatment (responder, partial responder and non-responder). Average MTR, qMT parameters, and CEST and rNOE contributions were calculated for each category. Significant changes were mostly observed in the necrotic/apoptotic regions of the tumour and were most evident in the qMT parameters. It may be possible to determine efficacy early on in the course of treatment based on the studied MR characteristics.

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