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Abstract #1518

Community-informed connectomics of cortical intrinsic organization in participants with subjective cognitive decline

Qian Chen1, Jilei Zhang2, and Bing Zhang1
1Department of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China, 2Philips Healthcare, Shanghai, China

Individuals with subjective cognitive decline (SCD) were at higher risk of Alzheimer’s disease. Based on community-informed connectome analysis, we observed decreased intra-module connectivity in superior occipital gyrus of the visual network and decreased inter-module connectivity in supramarginal gyrus of the dorsal attention network in SCD subjects. The SCD group also showed increased intra-module connectivity in the dorsolateral prefrontal cortex and middle frontal gyrus of the frontoparietal network. The altered network measures showed significant correlations with cognitive performance on memory and language. Our findings may benefit a better understanding of the neural basis underlying early cognitive decline in the SCD stage.

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