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Abstract #1521

BOLD-fMRI repetition suppression versus enhancement: assessing habituation to emotional faces through the migraine cycle

Catarina Domingos1, Amparo Ruiz-Tagle1, Ana Fouto1, Inês Esteves1, Raquel Gil-Gouveia2, and Patrícia Figueiredo1
1Institute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, 2Neurology Department, Hospital da Luz, Lisbon, Portugal

We investigated habituation in migraine, by measuring repetition effects to emotional faces using BOLD-fMRI, during all phases of the migraine cycle. We first performed simulations to determine the sensitivity of the proposed fMRI paradigm and respective BOLD deconvolution approach to detect repetition effects, and then applied this to real data. Simulations showed that a commonly used deconvolution approach was able to correctly estimate repetition effects provided that response delays did not significantly deviate from default. When applied to real data, we found that controls exhibited the normal repetition suppression, but patients exhibited response maintenance or even potentiation.

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