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Abstract #1523

Data-driven analysis of Cerebrovascular Reactivity Mapping with Breath-Hold BOLDMRI in Patients with gliomas 

Mei-Yu Yeh1,2, Ping Hou2, and Ho-Ling Liu 2
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Houston, TX, United States

Cerebrovascular reactivity (CVR) mapping can be achieved by BOLD MRI during hypercapnia challenges, such as a breath-hold (BH) task. It has wide applications for the assessment of various neurological deficits and neurovascular uncoupling. The BH MRI is typically analyzed by modeling with a hemodynamic or respiratory response function and account for latencies in signal time courses. Accurate modeling requires physiological monitoring and/or consistent patient performance during the scan. Because the BOLD signal response to the BH is a global effect, this study proposes to utilize the individual’s whole-brain signal average as a regressor for the analysis of BH MRI.

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