Abstract #1539

Validity and repeatability of MRF in glioma and normal appearing contralateral brain tissue at 3T

Simran Kukran^1,2, Joely Smith^3,4, Luke Dixon^1,3, Ben Statton⁵, Sarah Cardona³, Lillie Pakzad-Shahabi^6,7, Matthew Williams^6,8, Dow-Mu Koh^2,9, Rebecca Quest^3,4, Matthew Orton², and Matthew Grech-Sollars^1,3

¹Department of Surgery and Cancer, Imperial College London, London, United Kingdom, ²Department of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, ³Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, ⁴Department of Bioengineering, Imperial College London, London, United Kingdom, ⁵Medical Research Council, London Institute of Medical Sciences, Imperial College London, London, United Kingdom, ⁶Computational Oncology group, Institute for Global Health Innovation, Imperial College London, London, United Kingdom, ⁷John Fulcher Neuro-oncology Laboratory, Department of Brain Sciences, Imperial College London, London, United Kingdom, ⁸Radiotherapy Department, Charing Cross Hospital, London, United Kingdom, ⁹Department of Radiology, Royal Marsden Hospital, London, United Kingdom

MR Fingerprinting (MRF) was found to give highly repeatable T1 and T2 measurements in glioma and normal appearing contralateral brain tissue. Validity was investigated via comparison to standard mapping techniques: variable flip angle for T1 and multi-echo spin echo for T2. Biases were found between MRF and standard relaxometry methods, as in previous healthy volunteer studies. Statistically significant strong and moderate correlations were found between the MRF and standard mapping methods for T1 and T2 respectively, indicating MRF is comparably sensitive to changes in T1 and T2 as established mapping techniques in both cancerous and normal appearing contralateral brain tissue.

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