Abstract #1555

Whole-knee quantification of the articular cartilage: magnetic resonance fingerprinting for joint T1 and T2* mapping of 16 slices in 3 minutes

Telly Ploem¹, Jaap Boon¹, Ingo Hermann^1,2, Cole S. Simpson³, Joe F Juffermans⁴, Tom M. Piscaer⁵, Hildo J Lamb⁴, Nazli Tümer⁶, Joao Tourais¹, and Sebastian Weingärtner¹

¹Magnetic Resonance Systems Lab, Department of Imaging Physics, Delft University of Technology, Delft, Netherlands, ²Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ³Department of Mechanical Engineering, Stanford University, Stanford, CA, United States, ⁴Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁵Orthopaedic Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands, ⁶Department of Biomechanical Engineering, Delft University of Technology, Delft, Netherlands

Quantitative tissue characterization of the articular cartilage is a promising method for early assessment of degeneration. However, current techniques have limited spatial coverage and are at risk of missing localized alterations. In this work, we implemented and validated an MRF-EPI sequence for the simultaneous T1 and T2* quantification with whole knee coverage across 16 slices in 3 minutes. Initial evaluation in phantom, ex vivo animal tissue and in one healthy subject show promising results compared with conventional methods.

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