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Abstract #1555

Whole-knee quantification of the articular cartilage: magnetic resonance fingerprinting for joint T1 and T2* mapping of 16 slices in 3 minutes 

Telly Ploem1, Jaap Boon1, Ingo Hermann1,2, Cole S. Simpson3, Joe F Juffermans4, Tom M. Piscaer5, Hildo J Lamb4, Nazli Tümer6, Joao Tourais1, and Sebastian Weingärtner1
1Magnetic Resonance Systems Lab, Department of Imaging Physics, Delft University of Technology, Delft, Netherlands, 2Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 3Department of Mechanical Engineering, Stanford University, Stanford, CA, United States, 4Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 5Orthopaedic Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands, 6Department of Biomechanical Engineering, Delft University of Technology, Delft, Netherlands

Quantitative tissue characterization of the articular cartilage is a promising method for early assessment of degeneration. However, current techniques have limited spatial coverage and are at risk of missing localized alterations. In this work, we implemented and validated an MRF-EPI sequence for the simultaneous T1 and T2* quantification with whole knee coverage across 16 slices in 3 minutes. Initial evaluation in phantom, ex vivo animal tissue and in one healthy subject show promising results compared with conventional methods.

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