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Abstract #1566

An Efficient Approach to Optimal Design of MR Fingerprinting Experiments with B-Splines

Evan Scope Crafts1 and Bo Zhao1,2
1Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, United States, 2Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, United States

Optimal design of acquisition parameters utilizing the Cramer-Rao bound provides improved SNR efficiency for MR fingerprinting experiments. The early work demonstrates that smooth magnetization evolutions resulting from constraining the flip angle variation lead to improved estimation performance. Here we introduce a new formulation, in which we constrain the sequence of acquisition parameters in the low-dimensional spline space. The proposed formulation enforces smooth magnetization evolutions with significantly reduced degrees of freedom. Compared to the state-of-the-art experiment design approach, it improves the computational efficiency by two orders of magnitude, while achieving a similar or slightly better SNR efficiency of the imaging experiments.

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