Abstract #1607

Development of a multiplexed ERETIC-RF array coil for quantitative whole brain 3D-MR spectroscopic imaging (MRSI)

Bijaya Thapa^1,2, Bernhard Strasser^1,2, Xianqi Li^1,2, Jason Stockman^1,2, Azma Mareyam¹, Boris Keil³, Zhe Wang⁴, Stefan Carp^1,2, Yulin V. Chang⁴, Lawrence Wald^1,2, Philipp Hoecht Hoecht⁵, and Ovidiu Andronesi^1,2

¹Dept. of Radiology, MGH, A. A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Mittelhessen University of Applied Science, Giessen, Germany, ⁴Siemens Medical Solutions USA, Charlestown, MA, United States, ⁵Siemens Healthcare, Erlangen, Germany

An Electronic REference To access In vivo Concentrations (ERETIC) to absolutely quantify the brain metabolites for 3D-MRSI using an array coil was developed. The challenge of ERETIC for large receive arrays is that the addition of many ERETIC channels might negatively impact B0 and B1 homogeneity and increase the unwanted channel cross-talk. Here we investigated whether the number of ERETIC channels can be reduced below the number of RF receive elements. We also developed a unique method to coil combine the ERETIC and receive array signal. Metabolite concentration maps obtained with ERETIC were compared to internal water reference method.

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