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Abstract #1607

Development of a multiplexed ERETIC-RF array coil for quantitative whole brain 3D-MR spectroscopic imaging (MRSI)

Bijaya Thapa1,2, Bernhard Strasser1,2, Xianqi Li1,2, Jason Stockman1,2, Azma Mareyam1, Boris Keil3, Zhe Wang4, Stefan Carp1,2, Yulin V. Chang4, Lawrence Wald1,2, Philipp Hoecht Hoecht5, and Ovidiu Andronesi1,2
1Dept. of Radiology, MGH, A. A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Mittelhessen University of Applied Science, Giessen, Germany, 4Siemens Medical Solutions USA, Charlestown, MA, United States, 5Siemens Healthcare, Erlangen, Germany

An Electronic REference To access In vivo Concentrations (ERETIC) to absolutely quantify the brain metabolites for 3D-MRSI using an array coil was developed. The challenge of ERETIC for large receive arrays is that the addition of many ERETIC channels might negatively impact B0 and B1 homogeneity and increase the unwanted channel cross-talk. Here we investigated whether the number of ERETIC channels can be reduced below the number of RF receive elements. We also developed a unique method to coil combine the ERETIC and receive array signal. Metabolite concentration maps obtained with ERETIC were compared to internal water reference method.

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