2D quiescent-interval slice-selective (QISS) MRA is an established technique in peripheral artery disease (PAD), however, its slice thickness is inferior to that used for computed tomography angiography (CTA). The prototype thin-slab stack-of-stars (tsSOS) QISS technique achieves CTA-like slice thickness. In this three-center study, we compared 2D-QISS and tsSOS-QISS MRA for the detection PAD in 23 patients. Overall image quality was not different between tsSOS-QISS and 2D-QISS. AUCs for PAD detection were not statistically different between the techniques (P=0.336). Our results indicate that 3D tsSOS-QISS provides similar accuracy in patients with PAD to a standard commercially available 2D-QISS technique.