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Abstract #1626

Predicting In Vivo Signal Intensity in Contrast Enhanced MRA Based on Blood Concentration of Gadolinium-Based Contrast Agents

Evan Norris1, Guenther Schneider2, Toshimasa Clark1, Miles Kirchin3, Gregory Wilson4, and Jeffrey Maki1,4
1Radiology, University of Colorado, Aurora, CO, United States, 2University Hospital of Saarland, Homburg, Germany, 3Bracco Imaging, Milan, Italy, 4University of Washington, Seattle, WA, United States

Recent insight into the behavior of blood R1 and R2* predicts the precise manner that signal intensity increases, plateaus, and ultimately diminishes with increasing gadolinium-based contrast agent concentration ([GBCA]). This has important implications for optimal GBCA utilization and administration in contrast enhanced MRA (CE-MRA). We validate these theoretical constructs in an in vivo pig model where time resolved CE-MRA and [GBCA] (via mass spectrometry) are acquired simultaneously, demonstrating that the theoretical relationship between [GBCA] and R1, R2* as applied to first pass CE-MRA allows for accurate predictions of CE-MRA signal intensity for any given blood concentration across three different GBCAs.

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