Recent insight into the behavior of blood R1 and R2* predicts the precise manner that signal intensity increases, plateaus, and ultimately diminishes with increasing gadolinium-based contrast agent concentration ([GBCA]). This has important implications for optimal GBCA utilization and administration in contrast enhanced MRA (CE-MRA). We validate these theoretical constructs in an in vivo pig model where time resolved CE-MRA and [GBCA] (via mass spectrometry) are acquired simultaneously, demonstrating that the theoretical relationship between [GBCA] and R1, R2* as applied to first pass CE-MRA allows for accurate predictions of CE-MRA signal intensity for any given blood concentration across three different GBCAs.
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