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Abstract #1628

Quantitative evaluation of signal intensity threshold for carotid plaque components in cardiovascular MR imaging: Validation by histology

Dongye Li1, Huiyu Qiao2, Yongjun Qiao2, Hualu Han2, Dandan Yang2, Jingli Cao3, Huimin Xu4, Tao Wang4, Jun Shen1, and Xihai Zhao2
1Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, 2Department of Biomedical Engineering, Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China, 3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 4Peking University Third Hospital, Beijing, China

It is important to accurately identify carotid necrotic core (NC), intraplaque hemorrhage (IPH) due to its strong association with ischemic stroke. Multi-contrast cardiovascular magnetic resonance (CMR) vessel wall imaging has become an effective non-invasive technique to assess carotid plaque components. The aim of this study sought to confirm criteria of signal intensity threshold of all plaque components by comparing multiple tissue references validated by histology. This study afforded a standard of the signal intensity threshold ratio of carotid plaque components compared to reference tissues on multi-contrast cardiovascular MR imaging, and provides the basis for accurate identification of crucial plaque components.

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