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Abstract #1630

Quantitative MRI to compare vascular health in nonsmokers, smokers, and vapers.

Alessandra Caporale1, Michael Langham1, and Felix W Wehrli1
1Radiology, Laboratory for Structural, Physiologic and Functional Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

To investigate the effects of chronic exposure to cigarette smoke or electronic cigarette aerosol on the vascular endothelium, various MRI parameters were examined in an ongoing study involving healthy young people (mean age<30y). Peripheral, cerebrovascular reactivity, and central aortic stiffness were evaluated comparing smokers (N=11) and vapers (N=15) to their nonsmoking-peers (N=31). There were no significant differences between groups, but hyperemic blood flow acceleration trended lower in smokers/vapers while arterial stiffness trended higher in smokers, relative to nonsmokers. The findings may suggest that exposure in these young subjects was not be sufficient to cause measurable adverse effects on the endothelium.

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