Preterm children often accompany undesirable neurodevelopmental outcomes. Adequate cerebral blood flow (CBF) is essential to brain development and function. However, little is known about relationship among preterm birth, CBF and neurodevelopmental outcome. This study aims to investigate the effect of preterm birth on CBF and explore the relationship between CBF and neurodevelopmental score. Our results suggest that the effects of preterm birth on intellectual development are long lasting and extend even into late childhood. After controlling for age, CBF shows positive correlations with mental and psychomotor development indexes in left frontal and occipital lobes in preterm children.