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Abstract #1633

Developmental trajectories of cerebral blood flow and neurodevelopmental score in preterm children from 28 days to 13 years

Peiyao Chen1, Chao Jin1, Xianjun Li1, Miaomiao Wang1, Congcong Liu1, Xiaoyu Wang1, Fan Wu1, Yuli Zhang1, Cong Tian1, Mengxuan Li1, Xiaocheng Wei2, and Jian Yang1
1First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an, Shaanxi, China, 2MR Research China, GE Healthcare, Beijing, China

Preterm children often accompany undesirable neurodevelopmental outcomes. Adequate cerebral blood flow (CBF) is essential to brain development and function. However, little is known about relationship among preterm birth, CBF and neurodevelopmental outcome. This study aims to investigate the effect of preterm birth on CBF and explore the relationship between CBF and neurodevelopmental score. Our results suggest that the effects of preterm birth on intellectual development are long lasting and extend even into late childhood. After controlling for age, CBF shows positive correlations with mental and psychomotor development indexes in left frontal and occipital lobes in preterm children.

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