Abstract #1652

In vivo imaging of cerebral glutamate changes using chemical exchange saturation transfer MRI in a rat forced swimming test model of depression

Do-Wan Lee¹, Hwon Heo², Jae-Im Kwon³, Yeon Ji Chae², Joongkee Min³, Monica Young Choi², Chul‐Woong Woo³, Dong‐Cheol Woo^2,3, Kyung Won Kim¹, Jeong Kon Kim¹, Hyo Jeong Chin⁴, and Dong‐Hoon Lee⁴

¹Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ²Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ³Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁴Department of Radiological Science, College of Health Sciences, Yonsei University, Wonju, Korea, Republic of

Glutamate-weighted chemical exchange saturation transfer (GluCEST) imaging is a novel enhancement technique for the non-invasive detection and quantification of cerebral glutamate levels in neuro-molecular processes. The present study quantitatively evaluated glutamate signal changes in the hippocampal region of a rat forced swimming test model (FS) of depression. The GluCEST and proton magnetic resonance spectroscopy results showed that GluCEST values and glutamate concentrations were significantly lower in the FS rats than in the controls. These findings might provide a key marker to better understand the cerebral neurochemical responses in depressive disorders.

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