Abstract #1671

Power spectral density of salience network alterations in obsessive-compulsive disorder: Impact on thought-action fusion performance

Eunji Kim¹, Sang Won Lee², Hyunsil Cha¹, Heajung Choi¹, Seungho Kim¹, Yunheung Kim³, Seung Jae Lee², and Yongmin Chang⁴

¹Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, ²Psychiatry, Kyungpook National University Hospital, Daegu, Korea, Republic of, ³Kyungpook National University, Daegu, Korea, Republic of, ⁴Radiology and Molecular Medicine, Kyungpook National University, Daegu, Korea, Republic of

Obsessive-compulsive disorder (OCD) showed the functional connectivity alterations in default mode network (DMN), central executive network (CEN) and salience network (SN)¹. We investigated the difference of intrinsic networks between OCD and healthy controls (HC) from thought-action fusion (TAF) task and resting state by using fMRI. During TAF task, Power spectral density (PSD) of SN in OCD showed lower than PSD in HC in low-frequency bins. PSD of SN showed a significant correlation with TAF score and OBQ scale in OCD. Therefore when doing TAF task, OCD symptoms might have relations with alterations of PSD of SN.

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