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Abstract #1675

Free-Water Eliminated DTI Measures of Neuro-inflammation and White Matter Structural Deterioration in HIV-1 Clade C Infection

Teddy Salan1, Deepika Aggrawal2, Gaurav Garg2, Manju Mohanty2, Paramjeet Singh2, Mahendra Kumar1, Sameer Vyas2, and Varan Govind1
1University of Miami, Miami, FL, United States, 2Post Graduate Institute of Medical Education & Research, Chandigarh, India

Few neuroimaging studies have focused on HIV-1 clade C infection (HIV-1C) which comprises approximately half the global HIV population. In this work, we use a free-water eliminated diffusion tensor imaging (FWE-DTI) data processing approach to determine the extent of micro-structural brain damage in drug-naïve HIV-1C subjects. Our results show white matter (WM) structural abnormalities among HIV-1C subjects, manifested by increases in free water volume throughout the brain and reduced FWE fractional anisotropy (FWE-FA) along WM tracts. Our FWE-DTI approach provides an improved method for more accurate measures of brain abnormalities due to neuro-inflammation in HIV and other infections.

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