Clinical symptoms in Duchenne muscular dystrophy (DMD) not only affect the skeletal muscle but also the brain. We explored brain volume changes over a 2-4 year period in adolescents with DMD versus healthy controls (HC). Our preliminary results show no difference in growth curves between groups. We found a consistently lower total grey matter volume and no differences in white matter volume in DMD. Our data suggest that the differences in brain volume in DMD are non-progressive within the assessed age range of 8-20 years.