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Abstract #1677

Preliminary results of longitudinal brain volume analyses in adolescents with Duchenne muscular dystrophy

Mariken C.R. Hoegen1,2, Nathalie Doorenweerd1,2,3, Emma M. Broek1, Kieren G. Hollingsworth4, Chiara Marini Bettolo5, Jos G.M. Hendriksen 6,7, Erik H. Niks2,8, Volker Straub3, and Hermien E. Kan1,2
1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Duchenne Center Netherlands, Leiden, Netherlands, 3John Walton Muscular Dystrophy Research Centre, Newcastle upon Tyne, United Kingdom, 4Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, 5Faculty of Medical Sciences, John Walton Muscular Dystrophy Research Centre, Newcastle upon Tyne, United Kingdom, 6Expertise Center Kempenhaeghe, Heeze, Netherlands, 7Duchenne Center Netherlands, Heeze, Netherlands, 8Department of Neurology, Leiden University Medical Center, Leiden, Netherlands

Clinical symptoms in Duchenne muscular dystrophy (DMD) not only affect the skeletal muscle but also the brain. We explored brain volume changes over a 2-4 year period in adolescents with DMD versus healthy controls (HC). Our preliminary results show no difference in growth curves between groups. We found a consistently lower total grey matter volume and no differences in white matter volume in DMD. Our data suggest that the differences in brain volume in DMD are non-progressive within the assessed age range of 8-20 years.

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