Abstract #1677

Preliminary results of longitudinal brain volume analyses in adolescents with Duchenne muscular dystrophy

Mariken C.R. Hoegen^1,2, Nathalie Doorenweerd^1,2,3, Emma M. Broek¹, Kieren G. Hollingsworth⁴, Chiara Marini Bettolo⁵, Jos G.M. Hendriksen ^6,7, Erik H. Niks^2,8, Volker Straub³, and Hermien E. Kan^1,2

¹Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Duchenne Center Netherlands, Leiden, Netherlands, ³John Walton Muscular Dystrophy Research Centre, Newcastle upon Tyne, United Kingdom, ⁴Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁵Faculty of Medical Sciences, John Walton Muscular Dystrophy Research Centre, Newcastle upon Tyne, United Kingdom, ⁶Expertise Center Kempenhaeghe, Heeze, Netherlands, ⁷Duchenne Center Netherlands, Heeze, Netherlands, ⁸Department of Neurology, Leiden University Medical Center, Leiden, Netherlands

Clinical symptoms in Duchenne muscular dystrophy (DMD) not only affect the skeletal muscle but also the brain. We explored brain volume changes over a 2-4 year period in adolescents with DMD versus healthy controls (HC). Our preliminary results show no difference in growth curves between groups. We found a consistently lower total grey matter volume and no differences in white matter volume in DMD. Our data suggest that the differences in brain volume in DMD are non-progressive within the assessed age range of 8-20 years.

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