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Abstract #1685

Demyelination is related to deep gray matter iron deposition in CADASIL patients

hui hong1, shuyue wang1, xinfeng Yu2, Yererfan Jiaerken2, Xiaojun Guan2, and minming zhang2
1radiology, Zhejiang University, hangzhou, China, 2radiology, the second affiliated hospital of zhejiang university, school of medicine, hangzhou, China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic cerebral small vessel disease. Apart from widespread white matter hyperintensities (WMHs), increased deep gray matter iron deposition was also suggested. Whether there is an association between white matter injury and deep gray matter iron deposition is undetermined. Iron deposition in deep gray matter was supposed due to the secondary degeneration followed by destroyed white matter integrity. Therefore, we investigate the iron deposition the relationship between white matter integrity and iron deposition to reveal the underlying mechanism of deep gray matter iron deposition in CADASIL patients.

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