Meeting Banner
Abstract #1705

Orthogonal diffusion tensor decomposition reveals age-related degeneration patterns in complex fibre architecture

Jordan A. Chad1,2, Ofer Pasternak3, and J. Jean Chen1,2
1Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Diffusion tensor imaging (DTI) consistently detects increased mean diffusivity (MD) and decreased fractional anisotropy (FA) with age in single white matter (WM) bundles, but findings have been inconsistent in more complex fibre architecture. In this study, an orthogonal moment tensor decomposition yields clear degeneration patterns across complex fibre architecture, indicating that apparent challenges of DTI in these regions were due to the choice of tensor decomposition rather than the DTI model itself. This study therefore presents a revised view of DTI of aging WM and indicates how degeneration in complex fibre architecture can manifest in forms other than decreased FA.

This abstract and the presentation materials are available to members only; a login is required.

Join Here