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Abstract #1726

Subsampling an existing diffusion MRI multi-shell scheme: impact on histogram measures derived from DTI and DKI

Ana R Fouto1, Rita G Nunes1, Amparo Ruiz-Tagle1, Marc Golub1, Inês Esteves1, Athanasios Vourvopoulos1, Raquel Gil-Gouveia2, Andreia C Freitas1, Nuno A Silva3, and Patrícia Figueiredo1
1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, 2Neurology Department, Hospital da Luz, Lisbon, Portugal, 3Learning Health, Hospital da Luz, Lisbon, Portugal

Multi-shell diffusion MRI sampling schemes require long acquisition times and are hence potentially compromised by poorer subject compliance. There is therefore a need to consider strategies to enable shortening the exam to ensure clinical feasibility, while maintaining cross-exam comparability. We analyzed the impact of subsampling a multi-shell scheme on the estimation of diffusion maps. In particular, we evaluated its effect on histogram-derived metrics computed over skeletonized maps of DTI and DKI parameters. Several metrics showed a significant effect of subsampling. This should be carefully considered depending on the effect size we are trying to measure on a patient’s population.

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