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Abstract #1770

A Marriage of Subspace Modeling with Deep Learning to Enable High-Resolution Dynamic Deuterium MR Spectroscopic Imaging

Yudu Li1,2, Yibo Zhao1,2, Rong Guo1,2, Tao Wang3, Yi Zhang3, Mathew Chrostek4, Walter C. Low4, Xiao-Hong Zhu3, Wei Chen3, and Zhi-Pei Liang1,2
1Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 4Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States

Dynamic deuterium MR spectroscopic imaging (DMRSI) is a powerful metabolic imaging method, with great potential for tumor imaging. However, current DMRSI applications are limited to low spatiotemporal resolutions due to low sensitivity. This work overcomes this issue using a machine learning-based method. The proposed method integrates subspace modeling with deep learning to effectively use prior information for sensitivity enhancement and thus enables high-resolution dynamic DMRSI. Experimental results have been obtained from rats with and without brain tumor, which demonstrate that we can obtain dynamic metabolic changes with unprecedented spatiotemporal resolutions.

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