DMI in combination with oral administration of deuterated glucose could potentially be used to investigate glycolytic and oxidative glucose metabolism in skeletal muscle non-invasively. However, skeletal muscle is a tissue with a high degree of spatial organization. In this study, we investigated the effect of anisotropic motional averaging on 7T deuterium spectra of the lower leg muscles. We observed quadrupole moment splittings of the natural abundance HDO signal and showed that the size of these splittings depends on the angle between muscle fibers and the main magnetic field B0.
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