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Abstract #1786

Monitoring liver glucose uptake and metabolism with dynamic 3D deuterium metabolic imaging at 7T

Ayhan Gursan1, Arjan D. Hendriks1, Dimitri Welting1, Dennis W.J. Klomp1, and Jeanine J. Prompers1
1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Deuterium metabolic imaging (DMI) is an emerging method to assess metabolism in vivo. In this study, we applied dynamic 3D DMI with oral administration of deuterated glucose to investigate the dynamics of hepatic glucose uptake and metabolism at 7T. After glucose intake, the signal from deuterated glucose logarithmically increased in the liver and plateaued around 100 min, after which it decreased again, as a result of its conversion through glycolysis, oxidative metabolism and, probably the largest part, glycogen synthesis. DMI will be a valuable tool to study disturbances of liver metabolism in metabolic diseases.

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