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Abstract #1814

Conserving low amplitude resonances in tensor rank truncation for image enhancement of spectroscopic imaging data.

Alan J. Wright1, Richard Mair1,2,3, Anastasia Tsyben1, and Kevin M. Brindle1,3,4
1CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 2Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 3Cancer Research UK Major Centre-Cambridge, University of Cambridge, Cambridge, United Kingdom, 4Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

Tensor decomposition can be used for denoising magnetic resonance spectroscopic imaging (MRSI) data by reconstructing the data from a small number of ranks. Selecting too low an order can remove data from the reconstruction and alter peak amplitudes. A condition for selection of rank order is proposed that removes only noise from the reconstructed data and, therefore, preserves signals from low amplitude resonances. Denoising algorithms that apply this condition are demonstrated for metabolic imaging data sets obtained with hyperpolarised [1-13C]pyruvate and [6,6-2H]glucose in preclinical cancer models, which improve signal-to-noise and reduce the Cramér-Rao lower bound errors in peak fitting.

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