There is an increasing interest in characterizing tissue microstructure using multi-compartment diffusion MRI models involving multiple b values and diffusion times ($$$t_{diff}$$$s). However, previous models usually ignore water exchange between intra- and extracellular compartments, which limits the accuracy of the fitted model parameters and potentially their interpretation as indicators of disease progression or treatment response. Here, we propose a simplified biophysical model of solid tissues that allows derivation of the mean intracellular water lifetime ($$$\tau_{i}$$$) and other microstructural parameters (e.g., cell size d) simultaneously from the $$$t_{diff}$$$ dependence of diffusion MRI signals.
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